Hippocampal alterations in congenital learned helpless rats after electroconvulsive seizures detected with in vivo 1H MR-Spectroscopy at 9.4T
| Title | Hippocampal alterations in congenital learned helpless rats after electroconvulsive seizures detected with in vivo 1H MR-Spectroscopy at 9.4T |
| Publication Type | Conference Paper |
| Year of Publication | 2009 |
| Authors | Biedermann, S, Sartorius, A, Zheng, L, Vollmayr, B, Gass, P, Ende, G, Weber-Fahr, W |
| Conference Name | Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine |
| Date Published | apr |
| Abstract | Psychiatric patients suffer from the time-delayed onset of antidepressive treatments. Electroconvulsive treatment (ECT) has a more rapid acting onset of the antidepressive effect. With the help of high field 1H magnetic resonance spectroscopy at 9.4 T we examined congenital learned helpless (cLH) rats\’ hippocampi after a six days course of ECS. We found a significant increase in choline, glutamate and GABA concentrations after ECS. The increase of glutamate correlated significantly with an increase of GABA. Glutamine was unaltered by ECS. These results support the hypothesis of ECS induced neurogenesis and increased synaptic plasticity. |
| Citation Key | biedermann_hippocampal_2009 |