@article {482,
	title = {Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy.},
	journal = {Sci Rep},
	volume = {11},
	year = {2021},
	month = {2021 Feb 19},
	pages = {4234},
	abstract = {<p>Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) revealed changes in gray matter volume (GMV) in various disorders. However, the cellular basis of GMV changes has remained largely unclear. We correlated changes in GMV with cellular metrics by imaging mice with MRI and two-photon in vivo microscopy at three time points within 12\&nbsp;weeks, taking advantage of age-dependent changes in brain structure. Imaging fluorescent cell nuclei allowed inferences on (i) physical tissue volume as determined from reference spaces outlined by nuclei, (ii) cell density, (iii) the extent of cell clustering, and (iv) the volume of cell nuclei. Our data indicate that physical tissue volume alterations only account for 13.0\% of the variance in GMV change. However, when including comprehensive measurements of nucleus volume and cell density, 35.6\% of the GMV variance could be explained, highlighting the influence of distinct cellular mechanisms on VBM results.</p>
},
	issn = {2045-2322},
	doi = {10.1038/s41598-021-83491-8},
	author = {Asan, Livia and Falf{\'a}n-Melgoza, Claudia and Beretta, Carlo A and Sack, Markus and Lei Zheng and Weber-Fahr, Wolfgang and Kuner, Thomas and Knabbe, Johannes}
}
@article {sack2020interactive,
	title = {Interactive tool to create adjustable anatomical atlases for mouse brain imaging},
	journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
	year = {2020},
	pages = {1{\textendash}5},
	publisher = {Springer},
	author = {Sack, Markus and Lei Zheng and Gass, Natalia and Ende, Gabriele and Sartorius, Alexander and Weber-Fahr, Wolfgang}
}
@article {Gass_2018,
	title = {Antagonism at the NR2B subunit of NMDA receptors induces increased connectivity of the prefrontal and subcortical regions regulating reward behavior},
	journal = {Psychopharmacology},
	year = {2018},
	pages = {1{\textendash}14},
	issn = {0033-3158, 1432-2072},
	doi = {10.1007/s00213-017-4823-2},
	url = {https://link.springer.com/article/10.1007/s00213-017-4823-2},
	author = {Gass, Natalia and Becker, Robert and Sack, Markus and Schwarz, Adam J. and Reinwald, Jonathan and Cosa-Linan, Alejandro and Lei Zheng and Hohenberg, Christian Clemm von and Inta, Dragos and Meyer-Lindenberg, Andreas and Weber-Fahr, Wolfgang and Gass, Peter and Sartorius, Alexander}
}
@conference {426,
	title = {Interactive Tool to Create Adjustable Anatomical Atlases for Mouse Brain Imaging},
	booktitle = {Proc. Intl. Soc. Mag. Reson. Med. 26},
	year = {2018},
	url = {http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/2843.html},
	author = {Sack, Markus and Lei Zheng and Gass, Natalia and Sartorius, Alexander and Ende, Gabriele and Weber-Fahr, Wolfgang}
}
@article {Zheng_2016,
	title = {Influence of regional cerebral blood volume on voxel-based morphometry},
	journal = {NMR Biomed},
	volume = {29},
	year = {2016},
	month = {2016 Jun},
	pages = {787-95},
	abstract = {<p>The investigation of structural brain alterations is one focus in research of brain diseases like depression. Voxel-based morphometry (VBM) based on high-resolution 3D MRI images is a widely used non-invasive tool for such investigations. However, the result of VBM might be sensitive to local physiological parameters such as regional cerebral blood volume (rCBV) changes. In order to investigate whether rCBV changes may contribute to variation in VBM, we performed analyses in a study with the congenital learned helplessness (cLH) model for long-term findings. The 3D structural and rCBV data were acquired with T2 -weighted rapid acquisition with relaxation enhancement (RARE) pulse sequences. The group effects were determined by standard statistical parametric mapping (SPM) and biological parametric mapping (BPM) and examined further using atlas-based regions. In our genetic animal model of depression, we found co-occurrence of differences in gray matter volume and rCBV, while there was no evidence of significant interaction between both. However, the multimodal analysis showed similar gray matter differences compared with the standard VBM approach. Our data corroborate the idea that two group VBM differences might not be influenced by rCBV differences in genetically different strains. Copyright {\textcopyright} 2016 John Wiley \&amp; Sons, Ltd.</p>},
	issn = {1099-1492},
	doi = {10.1002/nbm.3519},
	author = {Lei Zheng and Cleppien, Dirk and Gass, Natalia and Falf{\'a}n-Melgoza, Claudia and Vollmayr, Barbara and Hesser, J{\"u}rgen and Weber-Fahr, Wolfgang and Sartorius, Alexander}
}
@conference {falfan-melgoza_longitudinal_2016,
	title = {Longitudinal VBM of downregulation in mice with striatum-specific D2R overexpression},
	booktitle = {Proc. Intl. Soc. Mag. Reson. Med. 24},
	year = {2016},
	url = {http://www.ismrm.org/16/program_files/EP17.htm},
	author = {Falf{\'a}n-Melgoza, Claudia and Mallien, Anne Stephanie and Lei Zheng and Sartorius, Alexander and Kellendonk, Christoph and Gass, Peter and Weber-Fahr, Wolfgang}
}
@article {371,
	title = {Exercise boosts hippocampal volume by preventing early age-related gray matter loss.},
	journal = {Hippocampus},
	volume = {24},
	year = {2014},
	month = {2014 Feb},
	pages = {131-4},
	keywords = {Aging, Animals, Cranial Irradiation, Hippocampus, Imaging, Three-Dimensional, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Physical Conditioning, Animal, Running},
	issn = {1098-1063},
	doi = {10.1002/hipo.22227},
	author = {Fuss, Johannes and Biedermann, Sarah V and Falf{\'a}n-Melgoza, Claudia and Auer, Matthias K and Lei Zheng and Steinle, J{\"o}rg and H{\"o}rner, Felix and Sartorius, Alexander and Ende, Gabriele and Weber-Fahr, Wolfgang and Gass, Peter}
}
@article {372,
	title = {Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula.},
	journal = {Eur Neuropsychopharmacol},
	volume = {24},
	year = {2014},
	month = {2014 Mar},
	pages = {381-90},
	keywords = {Animals, Brain, Brain Mapping, Cerebrovascular Circulation, Depressive Disorder, Treatment-Resistant, Habenula, Helplessness, Learned, Magnetic Resonance Imaging, Male, Neural Pathways, Rats, Rats, Sprague-Dawley, Signal Processing, Computer-Assisted},
	issn = {1873-7862},
	doi = {10.1016/j.euroneuro.2013.12.004},
	author = {Gass, Natalia and Cleppien, Dirk and Lei Zheng and Schwarz, Adam James and Meyer-Lindenberg, Andreas and Vollmayr, Barbara and Weber-Fahr, Wolfgang and Sartorius, Alexander}
}
